Louisville to St. Louis: where to stop

A stop about every 45 minutes

The best bet in each stretch: a likely-clean restroom first, then a travel center or gas. Estimates come from who runs the store until drivers review it.

• 92 Leavenworth · Marengo Mixedest. Pilot Truck Stop Leavenworth, Indiana 34 mi from Louisville 30 min in
• 25B Terre Haute Mixedest. Love's 101 mi from Louisville 1 hr 30 min in
• 130 Grayville · Carmi Mixedest. Road Ranger Grayville · 127 mi from Louisville 2 hr in
• 41 IL 177 Mixedest. Road Ranger Okawville · 216 mi from Louisville 3 hr 15 min in

Long stretches without a likely-clean stop

• 220 miles, about 3 hr 30 min: from Exit 105 (IN) to Exit 16 (IL). Stop before it if you can.

Other drives on I-64

• Lexington to St. Louis
• Louisville to Mount Vernon