Lexington to St. Louis: where to stop

A stop about every 45 minutes

The best bet in each stretch: a likely-clean restroom first, then a travel center or gas. Estimates come from who runs the store until drivers review it.

• 35 Shelbyville Likely cleanest. Cracker Barrel Shelbyville · 43 mi from Lexington 45 min in
• 105 Corydon Likely cleanest. Cracker Barrel Corydon · 96 mi from Lexington 1 hr 30 min in
• 57A US-231 South Mixedest. TA Express 145 mi from Lexington 2 hr 15 min in
• 130 Grayville · Carmi Mixedest. Road Ranger Grayville · 203 mi from Lexington 3 hr in
• 80 IL 37 Mixedest. Love's Travel Stop 252 mi from Lexington 4 hr in
• 16 O'Fallon · Shiloh Likely cleanest. Cracker Barrel O'Fallon · 316 mi from Lexington 4 hr 45 min in

Long stretches without a likely-clean stop

• 220 miles, about 3 hr 30 min: from Exit 105 (IN) to Exit 16 (IL). Stop before it if you can.

Other drives on I-64

• Lexington to Mount Vernon
• Louisville to St. Louis