St. Louis to Louisville: where to stop

A stop about every 45 minutes

The best bet in each stretch: a likely-clean restroom first, then a travel center or gas. Estimates come from who runs the store until drivers review it.

• 95 Mount Vernon · Ashley Likely cleanest. Cracker Barrel Mount Vernon · 75 mi from St. Louis 1 hr 15 min in
• 80 IL 37 Mixedest. Love's Travel Stop 80 mi from St. Louis 1 hr 15 min in
• 25A Evansville Mixedest. Love's 155 mi from St. Louis 2 hr 30 min in
• 57B US-231 North Mixedest. TA Express 187 mi from St. Louis 3 hr in

Long stretches without a likely-clean stop

• 66 miles, about 1 hr: from Exit 9 (IL) to Exit 95 (IL). Stop before it if you can.
• 161 miles, about 2 hr 30 min: from Exit 95 (IL) to Exit 105 (IN). Stop before it if you can.

Other drives on I-64

• St. Louis to Lexington
• Mount Vernon to Louisville